CA1186224A - Applicators for pharmacologically active agents, their preparation and use - Google Patents
Applicators for pharmacologically active agents, their preparation and useInfo
- Publication number
- CA1186224A CA1186224A CA000401976A CA401976A CA1186224A CA 1186224 A CA1186224 A CA 1186224A CA 000401976 A CA000401976 A CA 000401976A CA 401976 A CA401976 A CA 401976A CA 1186224 A CA1186224 A CA 1186224A
- Authority
- CA
- Canada
- Prior art keywords
- matrix element
- applicator
- film
- strip
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 238000002360 preparation method Methods 0.000 title abstract description 6
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- 238000000034 method Methods 0.000 claims abstract description 17
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- 229940125702 ophthalmic agent Drugs 0.000 claims description 36
- 238000005266 casting Methods 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 24
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- 229960003973 fluocortolone Drugs 0.000 description 1
- GAKMQHDJQHZUTJ-ULHLPKEOSA-N fluocortolone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@@H](C)[C@H](C(=O)CO)[C@@]2(C)C[C@@H]1O GAKMQHDJQHZUTJ-ULHLPKEOSA-N 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 229940020947 fluorescein sodium Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- ACGDKVXYNVEAGU-UHFFFAOYSA-N guanethidine Chemical compound NC(N)=NCCN1CCCCCCC1 ACGDKVXYNVEAGU-UHFFFAOYSA-N 0.000 description 1
- 229960003602 guanethidine Drugs 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940124512 hyoscine hydrobromide Drugs 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100001032 irritation of the eye Toxicity 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 229960004083 methazolamide Drugs 0.000 description 1
- FLOSMHQXBMRNHR-DAXSKMNVSA-N methazolamide Chemical compound CC(=O)\N=C1/SC(S(N)(=O)=O)=NN1C FLOSMHQXBMRNHR-DAXSKMNVSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229940074734 mydriatics and cycloplegics Drugs 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 239000002997 ophthalmic solution Substances 0.000 description 1
- 229960003502 oxybuprocaine Drugs 0.000 description 1
- CMHHMUWAYWTMGS-UHFFFAOYSA-N oxybuprocaine Chemical compound CCCCOC1=CC(C(=O)OCCN(CC)CC)=CC=C1N CMHHMUWAYWTMGS-UHFFFAOYSA-N 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 description 1
- 229960003733 phenylephrine hydrochloride Drugs 0.000 description 1
- HZOTZTANVBDFOF-PBCQUBLHSA-N physostigmine salicylate Chemical compound OC(=O)C1=CC=CC=C1O.C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C HZOTZTANVBDFOF-PBCQUBLHSA-N 0.000 description 1
- 229960002516 physostigmine salicylate Drugs 0.000 description 1
- 229960001416 pilocarpine Drugs 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
- 229960001289 prazosin Drugs 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- JDOZJEUDSLGTLU-VWUMJDOOSA-N prednisolone phosphate Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 JDOZJEUDSLGTLU-VWUMJDOOSA-N 0.000 description 1
- 229960002943 prednisolone sodium phosphate Drugs 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- LACQPOBCQQPVIT-SEYKEWMNSA-N scopolamine hydrobromide trihydrate Chemical compound O.O.O.Br.C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 LACQPOBCQQPVIT-SEYKEWMNSA-N 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- SKIVFJLNDNKQPD-UHFFFAOYSA-N sulfacetamide Chemical compound CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 SKIVFJLNDNKQPD-UHFFFAOYSA-N 0.000 description 1
- 229960002673 sulfacetamide Drugs 0.000 description 1
- IHCDKJZZFOUARO-UHFFFAOYSA-M sulfacetamide sodium Chemical compound O.[Na+].CC(=O)[N-]S(=O)(=O)C1=CC=C(N)C=C1 IHCDKJZZFOUARO-UHFFFAOYSA-M 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229920002725 thermoplastic elastomer Polymers 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960001288 triamterene Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8113343 | 1981-04-30 | ||
| GB8113343 | 1981-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1186224A true CA1186224A (en) | 1985-04-30 |
Family
ID=10521501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000401976A Expired CA1186224A (en) | 1981-04-30 | 1982-04-29 | Applicators for pharmacologically active agents, their preparation and use |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4540408A (en]) |
| EP (1) | EP0064841B1 (en]) |
| JP (1) | JPS57185870A (en]) |
| AT (1) | ATE14527T1 (en]) |
| AU (1) | AU550751B2 (en]) |
| CA (1) | CA1186224A (en]) |
| DE (1) | DE3265043D1 (en]) |
| GB (1) | GB2097680B (en]) |
| NZ (1) | NZ200429A (en]) |
| ZA (1) | ZA822975B (en]) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3513288A1 (de) * | 1985-04-13 | 1986-10-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Verfahren und vorrichtung zur beaufschlagung von augenstaebchen mit wirkstoffloesungen oder -suspensionen |
| US4795421A (en) * | 1986-04-25 | 1989-01-03 | Chesebrough-Pond's Inc. | Oral hygiene swab |
| US4778457A (en) * | 1986-11-06 | 1988-10-18 | York Kenneth K | Disposable applicator |
| USD302338S (en) | 1987-01-14 | 1989-07-18 | Philippi Randy J | Ointment applicator |
| US5028431A (en) * | 1987-10-29 | 1991-07-02 | Hercon Laboratories Corporation | Article for the delivery to animal tissue of a pharmacologically active agent |
| US4834654A (en) * | 1988-04-12 | 1989-05-30 | Nussbaum William J | Dental prosthesis applicator |
| GB8917217D0 (en) * | 1989-07-27 | 1989-09-13 | Smith & Nephew | Ophthalmic compositions |
| GB8917216D0 (en) * | 1989-07-27 | 1989-09-13 | Smith & Nephew | Ophthalmic composition |
| US5300018A (en) * | 1990-08-24 | 1994-04-05 | Apdyne Medical Company | Applicator means for the application of anesthetizing fluids and the like to the tympanic membrane |
| HK1007102A1 (en) * | 1992-10-13 | 1999-04-01 | Alcon Laboratories, Inc. | Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma |
| US5314419A (en) * | 1992-10-30 | 1994-05-24 | Pelling George E | Method for dispensing ophthalmic drugs to the eye |
| US5433714A (en) * | 1993-04-06 | 1995-07-18 | Bloomberg; Leroy | Topical anesthesia method for eye surgery, and applicator therefor |
| US5631004A (en) * | 1993-09-30 | 1997-05-20 | Alcon Laboratories, Inc. | Use of sustained release antibiotic compositions in ophthalmic surgical procedures |
| US5545617A (en) * | 1993-11-12 | 1996-08-13 | The Schepens Eye Research Institute, Inc. | Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion |
| DE19508029C2 (de) * | 1995-03-07 | 1997-10-09 | Richard Prof Dr Sueverkruep | Darreichungsform zur äußerlichen Applikation von ophthalmischen Arzneistoffen und Verfahren zur Herstellung derselben |
| US6172054B1 (en) | 1995-06-15 | 2001-01-09 | Alcon Laboratories, Inc. | Combination therapy for lowering and controlling intraocular pressure |
| US6441047B2 (en) | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
| CA2237898A1 (en) * | 1995-11-17 | 1997-05-29 | Louis Desantis Jr. | Combination therapy for treating glaucoma |
| CN1155383C (zh) | 1995-12-21 | 2004-06-30 | 阿尔康实验室公司 | 某些异喹啉磺酰基化合物治疗青光眼及眼局部缺血的用途 |
| WO2000035365A1 (en) * | 1998-08-12 | 2000-06-22 | Ocular Research Of Boston, Inc. | Measurement of tear film break-up-time |
| US6159189A (en) * | 1998-08-12 | 2000-12-12 | Ocular Research Of Boston, Inc. | Method for instilling a controlled dose of fluid into the eye |
| US6306120B1 (en) * | 1999-06-07 | 2001-10-23 | Ben Gee Tan | Applicator and method for delivery of mitomycin to eye tissues during glaucoma filtering surgery |
| WO2002053158A1 (en) * | 2000-12-29 | 2002-07-11 | Alteon, Inc. | Method for treating glaucoma ib |
| WO2003051227A2 (en) * | 2001-12-14 | 2003-06-26 | Syed Rizvi | Feminine wipe for symptomatic treatment of vaginitis |
| US7780976B2 (en) * | 2002-05-30 | 2010-08-24 | Eye Care And Cure, Asia | Apparatus and method for delivering controlled quantities of one or more agents to the eye |
| US7018646B2 (en) * | 2002-05-30 | 2006-03-28 | Van Dalen Johan T W | Apparatus and method for delivering controlled quantities of one or more agents to the eye |
| US7244394B2 (en) * | 2002-10-03 | 2007-07-17 | Novartis Ag | Methods and kits for assays of analytes of interest in tears |
| DE10246900A1 (de) * | 2002-10-08 | 2004-04-22 | Horstmann, Michael, Dr. | Am Auge applizierbare Vorrichtung zur sicheren Dosierung systemischer und tropischer Medikation |
| DE10307762A1 (de) * | 2003-02-16 | 2004-09-09 | Stiftung Alfred-Wegener-Institut Für Polar- Und Meeresforschung | Viskoelastische Beschichtungspaste zum Schutz gegen Makrobewuchs und Verfahren zur Herstellung einer Beschichtung |
| EP1765454B1 (en) | 2004-07-02 | 2016-04-13 | Mati Therapeutics Inc. | Treatment medium delivery device for the eye |
| US7402156B2 (en) * | 2004-09-01 | 2008-07-22 | Alcon, Inc. | Counter pressure device for ophthalmic drug delivery |
| US7998497B2 (en) | 2006-03-31 | 2011-08-16 | Qlt Inc. | Nasolacrimal drainage system implants for drug therapy |
| EP3372205A1 (en) | 2007-09-07 | 2018-09-12 | Mati Therapeutics Inc. | Lacrimal implant detection |
| US20130226111A1 (en) * | 2010-07-29 | 2013-08-29 | Tsukioka Film Pharma Co., Ltd. | Drug support body, and method for producing same |
| US8496880B2 (en) * | 2011-04-01 | 2013-07-30 | Precision Laboratories, Inc. | Test strip construction |
| US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
| EP3120834A1 (en) | 2011-08-29 | 2017-01-25 | Mati Therapeutics Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
| US9642742B2 (en) * | 2012-10-02 | 2017-05-09 | Harold D. Mansfield | Eye drop applicator and drop transfer method |
| WO2014119587A1 (ja) * | 2013-01-29 | 2014-08-07 | 参天製薬株式会社 | 溶解分離層を備えた薬剤付き支持体 |
| US9320645B2 (en) * | 2013-05-29 | 2016-04-26 | Terry Glasser | Approach to administering ocular medication |
| EP3487480A4 (en) * | 2016-07-20 | 2019-07-24 | Ryan, Edwin | APPLICATOR OF OPHTHALMIC DROPS. |
| KR102467288B1 (ko) * | 2020-06-09 | 2022-11-17 | 동국대학교 산학협력단 | 결막 접촉용 약물 전달기 |
| CN116099114A (zh) * | 2021-11-10 | 2023-05-12 | 新旺生医股份有限公司 | 药物载具及其使用方法 |
| DE102021130950A1 (de) | 2021-11-25 | 2023-05-25 | Lts Lohmann Therapie-Systeme Ag. | Applikationshilfe |
| EP4547753A1 (en) * | 2023-04-27 | 2025-05-07 | Abletx Ltd. | Degradable elastomeric matrices, compositions comprising them, methods of preparing them and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3075527A (en) * | 1960-06-02 | 1963-01-29 | Chemway Corp | Sterile medicated strips |
| US3656481A (en) * | 1969-08-01 | 1972-04-18 | Richard A Ness | Magnetic ophthalmic instrument for eye therapy |
| US3625214A (en) * | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US3960150A (en) * | 1971-09-09 | 1976-06-01 | Alza Corporation | Bioerodible ocular device |
| SE374272B (en]) * | 1973-08-31 | 1975-03-03 | D A Safwat | |
| DK137946B (da) * | 1973-12-17 | 1978-06-12 | Merck & Co Inc | Bæremedium i fast form til anvendelse i ophthalmiske præparater. |
| US4036230A (en) * | 1976-08-18 | 1977-07-19 | Kenneth Waldock Adams | Medicinal insert instrument |
-
1982
- 1982-04-27 NZ NZ200429A patent/NZ200429A/en unknown
- 1982-04-29 US US06/373,288 patent/US4540408A/en not_active Expired - Fee Related
- 1982-04-29 EP EP82302203A patent/EP0064841B1/en not_active Expired
- 1982-04-29 GB GB8212482A patent/GB2097680B/en not_active Expired
- 1982-04-29 AU AU83134/82A patent/AU550751B2/en not_active Ceased
- 1982-04-29 AT AT82302203T patent/ATE14527T1/de not_active IP Right Cessation
- 1982-04-29 CA CA000401976A patent/CA1186224A/en not_active Expired
- 1982-04-29 DE DE8282302203T patent/DE3265043D1/de not_active Expired
- 1982-04-30 ZA ZA822975A patent/ZA822975B/xx unknown
- 1982-04-30 JP JP57074444A patent/JPS57185870A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57185870A (en) | 1982-11-16 |
| JPH0411229B2 (en]) | 1992-02-27 |
| ATE14527T1 (de) | 1985-08-15 |
| ZA822975B (en) | 1983-04-27 |
| US4540408A (en) | 1985-09-10 |
| EP0064841B1 (en) | 1985-07-31 |
| DE3265043D1 (en) | 1985-09-05 |
| AU550751B2 (en) | 1986-04-10 |
| AU8313482A (en) | 1982-11-04 |
| EP0064841A1 (en) | 1982-11-17 |
| GB2097680B (en) | 1985-05-30 |
| GB2097680A (en) | 1982-11-10 |
| NZ200429A (en) | 1984-10-19 |
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